Assuming he's got anything into unarmed defense - it works like a weaker version of iron hands.

Backfisting is the way to go for melee damage - it relies only on dodging his blows and doesn't involve his uber defenses, evade, or legacy skill dodge in any way. I took the master of Uraken edge and with 3 people fighting a hasted Nanorab, I'd be pumping out 2-3 unblockable mangles per round ontop of everything else. Freakin' awesome. Especially fighting at the destructor when it can be hard to redirect.

Yhorian