Yes

Had it with a spear mace arial, it synergized well with incarnadine and striking (until I think they changed striking to fire off of the base int/wis instead of adjusted int/wis)

There were times though near the beginning when incarnadine and cranial would drop int and wis so much that with striking charged a maledicted (low dex) person would be taking almost 8-10 hits a round.

On a zerker that was pretty mean.