I try to work out what my target is headed for, and overtake them, spamming murder or whatever, in the hope that they've stacked directions and are going to run into me.
Often it's quite obvious where your target is going:
If it's a rager, you can bet your bottom dollar that they're making a line for the big D.
If they quaff when bleeding, they're probably going to the nearest healer.
Etc.
Use this knowledge to your advantage - cut your opponent off, or run to where you think he is and bash that fool down.
