You might also enjoy Umineko No Naku Koro Ni, but unless you are the type that likes sophistry or logical mindfuckery or mystery novels and that sort of stuff, the anime itself is extremely compacted and the original visual novel drags on because it spends too much time fleshing things out and hiding clues in the narrative before getting to the actiony and emotional mindfuckery bits. If logic play, word games and puns aren't your thing, you aren't going to enjoy it even with the mature themes involved.
I tend to enjoy mature themes when I come across them, but since I'm such a casualfag anymore when it comes to these things (they are no fun to watch alone and I'd prefer to be gaming than sitting still watching things alone) when I do actually watch anything comedy and harem anime has a better shot at getting my attention when it's not soaked in moe.
Also, Big O popped into my head, but I've not watched it in-depth. It should still be along the lines of what you're looking for.
Edited 1 time(s). Last edit at 06/18/2014 06:59PM by Scrimbul.