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pintose
also I could be wrong on how this works but some times when you concoct grenades you get super grenades that hit the entire room for a lot more then normal damage. I believe these are created when you use legendary or famous ingredients. I can't confrim this through personal experience only to say that I have created the grenades that were super duper on occasion but I could not recall what I used to make them.
I've done this without using anything special. I'm betting money it's skill % related and level related.