I'm pretty much in the same boat as Auburn. The highlights for me:
1. Contrary to the whole pro-life facade, funding to Title X (which in turn funds groups like Planned Parenthood) has gone up during his tenure. (The money doesn't go towards abortion directly, but funding other wings of PP allows it to shift more of its budget towards those that *are* involved in providing abortion services.)
2. Contrary to the whole "fiscal conservative" facade, federal spending has gone way up during his tenure, even discounting costs associated with the Iraq war.
3. No Child Left Behind sucks. Big time. So much for being the party of small government. But worse yet, it's not even "good" big government.
4. The Bush administration's handling of national security post-9/11 has been totally reactionary and heavy-handed. I'll freely admit that "something needed to be done", but creating a new Cabinet-level position and chucking lots of previously sacrosanct constitutional liberties out the window ain't it.
5. Opening up federally protected lands for oil drilling.
6. Mismanagement of the boom times. Rather than hand out tax cuts when things were going well, maybe use some of that extra cash to pay down the debt? Maybe save it for a rainy day like, oh, the next time there's a recession?
7. The Iraq thing. I have no problem with the U.S. "flaunting international law" and acting unilaterally (Don't forget Poland!), but only when it's warranted. Iraq doesn't qualify.